Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.
Identifieur interne : 008023 ( Main/Exploration ); précédent : 008022; suivant : 008024Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions.
Auteurs : Leanne M. Fox [États-Unis] ; Susan F. Wilson ; David G. Addiss ; Jacky Louis-Charles ; Madsen V. Beau De Rochars ; Patrick J. LammieSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2005.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Analyse multivariée, Animaux, Antigènes d'helminthe (sang), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Haïti (épidémiologie), Humains, Mâle, Noeuds lymphatiques (anatomopathologie), Orteils (anatomopathologie), Orteils (imagerie diagnostique), Orteils (parasitologie), Wuchereria bancrofti (isolement et purification), Échographie.
- MESH :
- anatomopathologie : Filariose lymphatique, Noeuds lymphatiques, Orteils.
- imagerie diagnostique : Filariose lymphatique, Orteils.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique, Orteils.
- sang : Antigènes d'helminthe.
- épidémiologie : Filariose lymphatique, Haïti.
- Adolescent, Adulte, Analyse multivariée, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Échographie.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antigens, Helminth (blood), Child, Child, Preschool, Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Female, Haiti (epidemiology), Humans, Lymph Nodes (pathology), Male, Multivariate Analysis, Toes (diagnostic imaging), Toes (parasitology), Toes (pathology), Ultrasonography, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , blood : Antigens, Helminth.
- diagnostic imaging : Elephantiasis, Filarial, Toes.
- epidemiology : Elephantiasis, Filarial, Haiti.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Toes.
- pathology : Elephantiasis, Filarial, Lymph Nodes, Toes.
- Adolescent, Adult, Animals, Child, Child, Preschool, Female, Humans, Male, Multivariate Analysis, Ultrasonography.
Abstract
To assess clinical findings associated with Wuchereria bancrofti infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (> or = 1 macerated lesion with involvement of > or = 4 toe web spaces) (P < 0.0001) and inguinal (P = 0.003) or crural (P = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions (P = 0.006) and inguinal lymph node pathology (P = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0-4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal (P = 0.01) and crural (P = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3-5) (P = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.
PubMed: 16222022
Affiliations:
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Fox</name><affiliation wicri:level="1"><nlm:affiliation>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. lfox@bu.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724</wicri:regionArea><wicri:noRegion>Georgia 30341-3724</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Susan F" sort="Wilson, Susan F" uniqKey="Wilson S" first="Susan F" last="Wilson">Susan F. Wilson</name></author><author><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name></author><author><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name></author><author><name sortKey="Beau De Rochars, Madsen V" sort="Beau De Rochars, Madsen V" uniqKey="Beau De Rochars M" first="Madsen V" last="Beau De Rochars">Madsen V. Beau De Rochars</name></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. 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Fox</name><affiliation wicri:level="1"><nlm:affiliation>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. lfox@bu.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemic Intelligence Service, Epidemiology Program Office, and Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724</wicri:regionArea><wicri:noRegion>Georgia 30341-3724</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Susan F" sort="Wilson, Susan F" uniqKey="Wilson S" first="Susan F" last="Wilson">Susan F. Wilson</name></author><author><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name></author><author><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name></author><author><name sortKey="Beau De Rochars, Madsen V" sort="Beau De Rochars, Madsen V" uniqKey="Beau De Rochars M" first="Madsen V" last="Beau De Rochars">Madsen V. Beau De Rochars</name></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antigens, Helminth (blood)</term><term>Child</term><term>Child, Preschool</term><term>Elephantiasis, Filarial (diagnostic imaging)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Haiti (epidemiology)</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Male</term><term>Multivariate Analysis</term><term>Toes (diagnostic imaging)</term><term>Toes (parasitology)</term><term>Toes (pathology)</term><term>Ultrasonography</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse multivariée</term><term>Animaux</term><term>Antigènes d'helminthe (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (imagerie diagnostique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Haïti (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Orteils (anatomopathologie)</term><term>Orteils (imagerie diagnostique)</term><term>Orteils (parasitologie)</term><term>Wuchereria bancrofti (isolement et purification)</term><term>Échographie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Noeuds lymphatiques</term><term>Orteils</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Toes</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Haiti</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Filariose lymphatique</term><term>Orteils</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Orteils</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Toes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymph Nodes</term><term>Toes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Haïti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Multivariate Analysis</term><term>Ultrasonography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse multivariée</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Échographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess clinical findings associated with Wuchereria bancrofti infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (> or = 1 macerated lesion with involvement of > or = 4 toe web spaces) (P < 0.0001) and inguinal (P = 0.003) or crural (P = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions (P = 0.006) and inguinal lymph node pathology (P = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0-4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal (P = 0.01) and crural (P = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3-5) (P = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G" last="Addiss">David G. Addiss</name><name sortKey="Beau De Rochars, Madsen V" sort="Beau De Rochars, Madsen V" uniqKey="Beau De Rochars M" first="Madsen V" last="Beau De Rochars">Madsen V. Beau De Rochars</name><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J" last="Lammie">Patrick J. Lammie</name><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name><name sortKey="Wilson, Susan F" sort="Wilson, Susan F" uniqKey="Wilson S" first="Susan F" last="Wilson">Susan F. Wilson</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Fox, Leanne M" sort="Fox, Leanne M" uniqKey="Fox L" first="Leanne M" last="Fox">Leanne M. Fox</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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